1 Mar

Mutations drive malignant melanoma

first_imgTwo mutations that collectively occur in 71 percent of malignant melanoma tumors have been discovered in what scientists call the “dark matter” of the cancer genome, where cancer-related mutations haven’t been previously found.Reporting their findings in the Jan. 24 issue of Science Express, Harvard Medical School (HMS) researchers at the Dana-Farber Cancer Institute and researchers at the Broad Institute said the highly “recurrent” mutations — occurring in the tumors of many people — may be the most common mutations in melanoma cells found to date.The researchers said these cancer-associated mutations are the first to be discovered in the vast regions of DNA in cancer cells that do not contain genetic instructions for making proteins. The mutations are located in non-protein-coding DNA that regulates the activity of genes.This non-coding DNA, much of which was previously dismissed as “junk,” accounts for 99 percent of a cell’s genome. A large number of oncogenic mutations in cancer have been identified in the past several decades, but all have been found within the actual genetic blueprints for proteins.“This new finding represents an initial foray into the ‘dark matter’ of the cancer genome,” said Levi Garraway, HMS associate professor of medicine and the article’s senior author.A human melanoma cell line growing in tissue culture is pictured. The study of cancer cell lines such as this one allows scientists to investigate cancer cell biological processes and ways to modify them in order to design and test new treatments. Image by Dlumen/iStock“In addition, this represents the discovery of two of the most prevalent melanoma gene mutations. Considered as a whole, these two TERT promoter mutations are even more common than BRAF mutations in melanoma. Altogether, this discovery could cause us to think more creatively about the possible benefits of targeting TERT in cancer treatment or prevention,” Garraway said.The mutations affect a promoter region — a stretch of DNA code that regulates the expression of a gene — adjacent to the TERT gene. TERT contains the recipe for making telomerase reverse transcriptase, an enzyme that can make cells virtually immortal, and is often found overexpressed in cancer cells. A promoter region of DNA controls the rate of a gene’s transcription — the copying of its DNA recipe into a message used by the cell to manufacture a protein.“We think these mutations in the promoter region are potentially one way the TERT gene can be activated,” said Franklin Huang, an HMS clinical fellow in medicine and co-first author of the report along with Harvard M.D.-Ph.D. student Eran Hodis.To investigate the mutation’s effect, the researchers hooked the mutant TERT promoter to a gene that makes luciferase, a light-emitting protein. They observed that the mutant promoter increased the production of luciferase in laboratory cell lines. In the same way, the scientists presume, the mutant promoter in human pigmented skin cells can send the TERT gene into overdrive, potentially contributing to the development of melanoma.The mutations were discovered when the scientists sifted through data from whole-genome sequencing of malignant melanoma tumors. Unlike “whole-exome” searches that examine only the protein-coding DNA of a cell’s genome, whole-genome searches scan all the DNA, including the non-coding regions.In analyzing whole-genome data, the investigators discovered the two somatic, or not-inherited, mutations in 17 of 19 (89 percent) of the tumors. Next, they sequenced a larger number of melanoma tumors and found that the two mutations were present in 71 percent of tumors in total.The researchers said the same mutations are present in cell lines from some other malignancies, and that preliminary evidence showed they might be unusually common in bladder and liver cancers. They also noted that the discovery of these important mutations in DNA previously not linked to cancer-causing alterations highlights the value of whole-genome searches of tumor DNA.Other authors include Mary Jue Xu, a student at Harvard Medical School; Gregory V. Kryukov of the Broad; and Lynda Chin of MD Anderson Cancer Center.The research was supported in part by the National Institutes of Health, the Mittelman Family Fellowship, the American Cancer Society, the Novartis Institutes for Biomedical Research, the Melanoma Research Alliance, and the Starr Cancer Consortium.This article was adapted from a Dana-Farber Cancer Institute news release.last_img read more

13 Aug

Pinot conquers Tourmalet as ‘weak’ Thomas fades in finale

first_imgFrance’s Thibaut Pinot raises his fist in victory after stage 14Paris, France | AFP | Thibaut Pinot conquered the Pyrenean summit of la Col du Tourmalet on Saturday with Julian Alaphilippe following him across the line to extend his overall Tour de France lead over defending champion Geraint Thomas, who admitted to feeling “weak”.Thomas, in fact, lost time for a second day running.After saying he had overheated when losing time Friday, he dropped another 29 seconds in the overall after being distanced by the lead group at the death.“I just didn’t feel quite on it from the start really to be honest — just quite weak,” said the 33-year-old Ineos man, claiming he had limited his losses. “So I decided to go at my own pace.”For British outfit Ineos, however, their co-captain Egan Bernal can go into the most mountainous culmination of a Tour in years in full confidence after he finished just a few seconds behind the winner at the first of seven summit finishes over 2000 metres.Pinot had vowed to attack this stage after losing time to an Ineos-led attack in a crosswind on the narrow road to Albi on Monday had angered him and his team.Thomas has two Frenchman to worry about and is now two minutes and two seconds behind Alaphilippe in the general classification after he started to suffer with 500 metres to go on Saturday.Alaphilippe was as surprised as anyone at Thomas wilting.“I saw great riders blow up before me and in the end I went for the win, it’s incredible,” said the 27-year-old soldier.French president Emmanuel Macron followed the whole stage from the lead car in the vast caravan and appeared animated as he was flanked on the podium by his two compatriots.“This man has heart,” he said looking at France’s current national hero Alaphilippe.On both the leader and Pinot, he added: “France is proud of them both.”As the 117km stage 14 climbed above the tree-line and above the mist where the oxygen levels were lower, contenders for the overall victory gradually fell by the wayside.By the end there were just five men remaining with Dutch Jumbo Visma captain Steven Kruijswijk third at 6sec, with German Emanuel Buchmann and Bernal another two seconds behind.Not only Ineos, but their rivals too may now switch their attention to young climber Bernal in light of Thomas’s underwhelming show. “Yesterday was one of the worst days of my career,” said the 22-year-old Bernal whose slender frame is unsuited to time-trialling.“Today I feel much better, the ascent was very hard and the best thing about it was managing to be amongst the best riders at the front.”– Pinot gets revenge on Ineos –Few expected the yellow jersey wearer Alaphilippe to thrive on Friday’s time-trial, which he won, and fewer still expected him to survive on the Tourmalet.But Alaphilippe dug deep and when he climbed out of the saddle to win the sprint for second, cheers for him were even louder than those for the popular Pinot.But after 10 stages in the lead, the attention switched from the overall leader to the stage winner.“Since the start of the Tour I’ve been targeting this stage, this is the one I wanted, the mythical Tourmalet,” said Pinot, who is placed sixth overall, 3mins 12sec off Alaphilippe.Pinot has long been thought a potential champion this year with the home nation waiting for its first Tour de France win since 1985.Fans had been weaving up the Tourmalet since dawn and there was a carnival atmosphere with almost as many Basque flags as French ones.Pinot, helped up the hill by young French champion David Gaudu, never faltered on the long final climb and his team boss at FDJ Marc Madiot was ecstatic at the finish.Madiot had been upset by comments from Ineos boss Dave Brailsford on Monday when Pinot dropped down the rankings after getting caught in a crosswind.“It feels good to twist the knife,” Brailsford said Monday.Madiot was seen screaming “yes, yes, yes” at the finish line before racing off to embrace his team leader.Share on: WhatsApplast_img read more

2 Aug

CALIFORNIA GOLD RUSH DAY TO FEATURE FIVE CAL-BRED OR SIRED STAKES ON SATURDAY, $200,000 SNOW CHIEF & $200,000 MELAIR SHARE TOP BILLING

first_imgMOTOWN MEN & SHIP IN JOY BOY HEAD FIELD OF 10 IN $150,000 TIZNOW STAKES La Fiera, a winner of the one mile turf Campanile Stakes at Golden Gate Fields April 26, and Sheer Pleasure, a rousing off the pace winner of Santa Anita’s Evening Jewel Stakes at 6 ½ furlongs, head a competitive field of seven 3-year-old fillies in Saturday’s $200,000 Melair Stakes, to be contested at a mile and a sixteenth.Owned and bred by Dr. and Mrs. William T. Gray and trained by Greg James, La Fiera broke her maiden for a $32,000 claiming tag going one mile on synthetic Tapeta four starts back at Golden Gate and has three wins from five starts. A dark bay or brown filly by Comic Strip out of the Roar mare Ms. Booty, La Fiera, who gets the services of Rafael Bejarano, will try natural dirt for the first time in the Melair. With earnings of $82,607, she’s proven a tractable sort and will likely stalk the early pace on Saturday.Trained by Phil D’Amato and owned by Little Red Feather Racing and R/M Racing, Sheer Pleasure rallied from far off the pace to take the state-bred Evening Jewel by three quarters of a length. A 6 ½ length first-out Cal-bred maiden special weight winner going six furlongs at Los Alamitos Dec. 19, Sheer Pleasure has two wins from four starts. A dark bay or brown filly by Birdonthewire, she is out of the Blare of Trumpets mare Kathryns Birthday and has earnings of $147,450.Second, beaten two lengths by La Fiera in the Campanile at Golden Gate April 16, trainer Peter Eurton’s Ashley’s Sassy was third, beaten five lengths by Sheer Pleasure two starts back in the Evening Jewel at Santa Anita. Owned by her breeders, Sharon Alesia, Bran Jam Stable and Ciaglia Racing, LLC, Ashley’s Sassy is 6-2-1-2 with earnings of $135,800. A two time sprint winner, she is by Decarchy and is out of the Urgent Request mare Ashely’s Folly.Third, beaten two lengths by La Fiera in the Campanile Stakes, Jack and Barbara Owens’ homebred Niassa was a close third five starts back in the one mile Soviet Problem Stakes versus state-breds at Los Alamitos Dec. 7 and rates serious consideration with Flavien Prat set to ride for the first time. A dark bay or brown filly by Papa Clem, she is out of the Tale of the Cat mare Glamour Cat and is 8-3-0-3 with earnings of $126,930.The complete field for the Melair Stakes, to be run as the seventh race on a 10-race card Saturday, with jockeys and weights in post position order: Barbara Beatrice, Tiago Pereira, 118; Thermodynamics, Gary Stevens, 118; Sheer Pleasure, Tyler Baze, 123; Niassa, Flavien Prat, 120; Ashley’s Sassy, Mike Smith, 120; La Fiera, Rafael Bejarano, 123, and Tribal Express, Alonso Quinonez, 118. GOLDEN GATE INVADER LA FIERA & LOCALLY BASED SHEER PLEASURE HEAD $200,000 MELAIR STAKES STAKES WINNER GO WEST MARIE HEADS FIELD IN FRAN’S VALENTINE STAKES RECENT STAKES WINNERS GRAZEN SKY & RICHARD’S BOY HEAD $200,000 SNOW CHIEF; FIELD OF 11 SOPHOMORES SET TO CONTEST 1 1/8 MILES ON TURF Motown Men heads a field of 10 California-bred or sired older horses in Saturday’s $150,000 Tiznow Stakes at a mile on the main track.Motown Men, who is trained by Ted West, was claimed out of a $40,000 optional claiming race March 8, won at a mile in an allowance race April 10 then went on to run a close third in the Grade III Precisionist going a 1 1/16 miles on the main track May 2.The 6-year-old gelding by Decarchy has one win and a second at the Tiznow distance and will again be ridden by Tyler Baze. He is owned by Gulliver Racing, LLC and is 28-5-6-5 overall with earnings of $294,459.Joy Boy ships in from Midwest for trainer Kellyn Gorder and returns once again to Santa Anita following his Gus Fonner Stakes win in Nebraska on April 25. The 7-year-old gelding by Tribal Rule has two wins, two seconds and third at the mile distance and will gain Joe Talamo as he breaks from the far outside in Saturday’s Tiznow.Joy Boy is owned by Kevin and Tammie Hulse of TK Stables, LLC and is 36-11-5-3- overall with earnings of $455,377.The complete field for the Tiznow Stakes, to be run as the ninth race on a 10-race card Saturday, with jockeys and weights in post position order: Solid Wager, Victor Espinoza, 121; Spirit Rules, Iggy Puglisi, 119; Toldeo Eddie, Drayden Van Dyke, 119; Magic Mark, Fernando Perez, 119; Short Heat Wave, David Flores, 121; Soi Phet, Kent Desormeaux, 124; Poshsky, Elvis Trujillo, 121; Rousing Sermon, Rafael Bejarano, 121; Motown Men, Tyler Baze, 121; Joy Boy, Joe Talamo, 124. GRADED STAKES WINNER HARLINGTON’S ROSE HEADS FIELD IN SPRING FEVER STAKES Stakes winner Go West Marie heads field of eight in Saturday’s Fran’s Valentine Stakes for California-bred or sired older fillies and mares going one mile on turf.Trained by Eddie Truman, Go West Marie will attempt to improve her perfect record at the Fran’s Valentine distance Saturday. Ridden by Gary Stevens in her last four starts, in which she has not finished worse than second, Go West Marie will retain the services of the Hall of Fame rider.A close second in the Grade III Las Cienegas turf sprint on April 11 and a winner of both the Irish O’Brien Stakes and the Sunshine Filly and Mare Turf Sprint Stakes earlier this year, Go West Marie will attempt a mile on the grass for just the second time.Owned by Peter Redekop, B.C Ltd, the 4-year-old filly by Western Fame is 19-6-2-5 overall with earnings of $482,520.Mike Puype’s Chati’s On Top is coming off two back-to-back wins in allowance company and will look to make the jump in class Saturday. A close second in the Campanile Stakes at Golden Gate on June 8 going a mile on the turf, she has one win, two seconds and a third overall at the Fran’s Valentine distance.Owned by Little Red Feather Racing and Marsha Naify she is 13-3-5-2 overall with earnings of $184,228.Trainer Jerry Hollendorfer will send out stakes winner Heat Du Jour. A winner of the Solana Beach Handicap at Del Mar on August 17 at a mile on turf, Heat Du Jour ran fifth in her next two stakes attempts; the Grade II Yellow Ribbon Handicap on Sept. 1 and the Oct. 4 Swingtime Stakes.Owned in part by Hollendorfer as well as Mark Schlaich and George Todaro, she is 26-5-2-4 overall with earnings of $263,910.The complete field for the Fran’s Valentine Stakes to be run as the sixth race on a 10-race card Saturday, with jockeys and weights in post position order: My Monet, Gonzalo Nicolas, 121; Wild in the Saddle, Rafael Bejarano, 124; Go West Marie, Gary Stevens, 121; Heat Du Jour, Corey Nakatani, 124; Chati’s On Top, Santiago Gonzalez, 121; Qiaona, Mike Smith, 119; Mangita, Aaron Gryder, 119; Chilada, Elvis Trujillo, 119. ARCADIA, Calif. (May 20, 2015)–A pair of $200,000 stakes, the Snow Chief, for 3-year-olds at 1 1/8 miles on turf and the Melair Stakes, for 3-year-old fillies at 1 1/16 miles on the main track, headline a total of five stakes restricted to horses bred or sired in California on Saturday, California Gold Rush Day, at Santa Anita.The Snow Chief, which attracted a field of 11, is headed by Grazen Sky and Richard’s Boy, both recent stakes winners, along with impressive allowance winners Rocko’s Wheel and Zinvor.Owned and bred by Nick Alexander and trained by Steve Miyadi, Grazen Sky, a grey or roan colt by Grazen out of the Sky Mesa mare Sky Marni, tried turf for the first time and pressed the pace en route to a 1 ¼ length win in the one mile Silky Sullivan Stakes on April 26 at Golden Gate Fields. The 6-5 favorite in a field of six state-breds, Grazen Sky followed up on a good second to highly regarded Gimme Da Lute in the 6 ½ furlong Echo Eddie Stakes at Santa Anita on April 4.With three wins and three seconds from six starts, Grazen Sky has earnings of $186,800. Like the rest of the field, he’ll try the deep waters of a mile and one eighth for the first time in the Snow Chief.Owned by Rockingham Ranch and conditioned by Peter Miller, Richard’s Boy comes off a neck win as the 9-5 favorite in the Desert Code Stakes, which was run at 6 ½ furlongs down Santa Anita’s hillside turf course May 2. A grey or roan gelding by Idiot Proof, Richard’s Boy finished third, a half length behind Grazen Sky two starts back in the Echo Eddie. With four wins from five starts, Richard’s Boy, who will try two turns for the first time, has earnings of $187,840.Owned by Little Red Feather Racing and co-breeder Jimmy Ukegawa, Rocko’s Wheel rallied from off the pace to take a 1 1/16 miles state-bred allowance by 1 ¾ lengths on April 26 and thus looms a serious contender given his proven ability to act around two turns. Trained by Phil D’Amato, Rocko’s Wheel earned a Snow Chief best last-out Beyer Speed figure of 89 and will try to transfer his recent sharp form onto turf, which he’ll try for the first time.A dark bay or brown colt by Grazen, Rocko’s Wheel is out of the Double Honor mare Honored Gold and was bred in-part by D’Amato’s mentor, the late Mike Mitchell. Rocko’s Wheel has two wins from four starts and earnings of $81,900.Trained by John Sadler and owned by Triple B Farms, Zinvor was a handy 2 ¼ length state-bred allowance winner going a mile on turf April 4, and with two wins from three tries on grass, he rates a huge chance in the Snow Chief. A dark bay or brown gelding by Tribal Rule out of the Woodman mare Shady Lady Dancer, Zinvor is 8-2-2-1 overall with earnings of $109,068.The complete field for the Snow Chief Stakes, to be run as the eighth race on a 10-race card Saturday, with jockeys and weights in post position order: Cardiac, Santiago Gonzalez, 118; Richard’s Boy, Fernando Perez, 123; Book Thirty Four, Felipe Valdez, 118; Zinvor, Victor Espinoza, 120; Grazen Sky, Rafael Bejarano, 123; Chief of Staff, Tyler Baze, 118; Temple Keys, Drayeden Van Dyke, 118; Neveradoubt, Flavien Prat, 118; Rocko’s Wheel, Joe Talamo, 120; Pulmarack, Corey Nakatani, 118, and Over Par, Mario Gutierrez, 118. Graded Stakes winner Harlington’s Rose heads the field in Saturday’s Spring Fever Stakes for California-bred or sired older fillies and mares going six furlongs.Winner of the Grade III Las Flores on March 8 at the Spring Fever distance, Harlington’s Rose has finished in the money in each of her last four starts, including a third place finish in the Grade II Santa Monica on Jan. 19 after a slow start.The Steve Knapp trainee will again be ridden by Joe Talamo who has been aboard for her last four starts. Harlington’s Rose is owned by Thomas Halasz, Ryan Johnson, Paul Newhart and partners and is 21-4-5-2 overall with earnings of $371,040.Philip D’Amato’s Sunday Rules will be looking for her fifth win in a row Saturday. The lightly raced 4-year-old filly by Tribal Rule broke her maiden at first asking in August 2013, went on to win the Generous Portion Stakes at Del Mar the same year then after a 10 month layoff returned to the races winning by 8 ¾ lengths in her 2014 debut at Santa Anita. After another approximate 10 month layoff, she won again on April 30 going 6 ½ furlongs in an optional allowance race and looks ready to go once again.Sunday Rules is owned by her breeder Nick Alexander and has $224,880 in earnings.The complete field for the Spring Fever Stakes to be run as the third race on a 10-race card Saturday, with jockeys and weights in post position order: Shakeitupbetty, Elvis Trujillo, 119; Harlington’s Rose, Joe Talamo, 123; Sidepocket Run, Tiago Pereira, 119; Meinertzhageni, Fernando Perez, 121; Sunday Rules, Tyler Baze, 121; Tribal Gal, Rafael Bejarano, 119. First post time on California Gold Rush Day is at 12:30 p.m. Admission gates open at 10:30 a.m.last_img read more

21 Dec

Anger as Speech and Language Therapist funding requests ‘ignored’

first_imgThe lack of funding for two senior Speech and Language Therapist posts in Donegal has been branded as unacceptable ignorance from the Department of Health.Donegal TD Charlie McConalogue has criticised the Minister for Health for not allocating funding for services for adults with intellectual disabilities, despite the applications being approved.Deputy McConalogue said he was informed by the HSE that Speech and Language Therapy Services submitted business cases for two Senior Speech and Language Therapist posts for Adult Intellectual Disability services in Donegal at the beginning of 2017. “Through my correspondence with the HSE I have discovered that despite the application submitted in 2017, no approval has yet been received for the posts. Indeed, I learned that the posts were included in their estimates for 2019 but no funding was received,” McConalogue said.The Fianna Fáil TD said it is unacceptable that there is currently no service for adults with intellectual disability in Donegal for their communication needs.“As it stands at present, adults with intellectual disability who require swallow assessment, are currently being seen with the Primary Care system and that is unfair and unacceptable.”Deputy McConalogue who raised the matter with the Minister in the Dáil recently, promised to keep the issue high on the agenda. “I have been informed that the HSE will include the posts again as a matter of priority in their 2020 estimates, so it is up to the Minister now to follow through with the necessary funding to ensure this vital service is available for the people of Donegal as a matter of urgency,” Deputy McConalogue concluded.Anger as Speech and Language Therapist funding requests ‘ignored’ was last modified: December 7th, 2019 by Staff WriterShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)last_img read more

19 Dec

Your Body Needs Its Nature Medicine

first_imgTrapping yourself indoors most of the day? Studies show that health improves with outdoor experiences in nature.Dose of nature is just what the doctor ordered (Medical Xpress). Australian and UK scientists found that people have better blood pressure and mental health when they visit parks 30 minutes or more each week. Given the urban pressures causing heart disease, stress, anxiety and depression, “savings to public health budgets across all health outcomes could be immense.”Get children playing outdoors to improve academic success and reduce obesity (Science Daily). Kids addicted to screens? Show them some reality outdoors and get their weight off. A study in Scotland showed that kids playing video games all day had multiple health problems. Health scientists recommend Unplug & Play: “Play benefits children in helping them to develop socially and emotionally, so promoting active outdoor play would have many benefits in addition to improving physical activity, improving academic attainment, and reducing obesity.”Running barefoot helps optimize technique, reduces risk of injury, study shows (Science Daily). Ever think about what the first humans experienced before shoes were invented? Except when walking around cactus or sharp rocks, they probably were more athletic. Barefoot running, while controversial, is still trending upward for scientific reasons.Barefoot running appears to contribute to the acquisition of a more efficient biomechanical running pattern, allowing contact between the foot and the ground to begin in the metatarsal area (forefoot strikes). The use of standard modern footwear appears to favour the opposite technique; initiating contact with the ground at the heel area with a rearfoot strike, which produces significant impact peaks that negatively affect the runner’s health and athletic performance.If these stories inspire you to become more active, here are some recent articles about exercise and health from Live Science.Will Staying Hydrated Help with Weight Loss? (Live Science)Meet Your Muscles: 6 Remarkable Human Muscles (Live Science)The 4 Types of Exercise You Need to Be Healthy (Live Science). Includes links to more detailed articlesModern conveniences are helpful, but not if they rob us of good health. We have innate capabilities that are tuned for interaction with nature. They do best when we connect them to their natural environment.Both creationists and evolutionists realize that the human body was designed to handle a wide variety of outdoor situations. Be all that you can be; explore your design!(Visited 17 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

18 Dec

SAA passes global environmental test

first_img11 June 2013 South African Airways (SAA) has become one of only six airlines in the world to be awarded “stage one” status in the International Air Transport Association’s (IATA’s) environmental assessment, the airline announced on Sunday. The IATA environmental assessment is a two-year programme to develop and establish an environmental standard and management system for over 240 IATA member airlines. The standard will involve general and on-board recycling, efficient flight and airport operations, limiting and reducing carbon emissions, general energy efficiency and environmentally conscious procurement procedures. SAA was invited by IATA to participate in the programme. “As part of SAA’s group environment strategy and in SAA’s continuous effort to become one of the world’s greenest airlines, our customers can fly assured that we are taking great steps to establish ourselves as a market leader when it comes to environmentally friendly operations, efficient aircraft, green buildings and environmentally conscious employees,” the airline’s spokesperson, Tlali Tlali, said in a statement. The IATA environmental assessment is the first environmental management system for the aviation sector. “I am delighted to announce that SAA has satisfied the independent assessors and passed the IATA environmental assessment stage one,” said IATA’s Paul Steele. “This makes SAA one of the world’s leading carriers in the areas of environmental responsibility and sustainability.” South African Airways aims to comply with applicable international regulations and integrating environmental concerns with all SAA’s planning and decision-making processes through the implementation of effective environmental management systems. It also involves working towards industry goals such as a cap on aviation carbon emissions from 2020, with the aim being carbon neutral growth, and an average improvement in fuel efficiency of 1.5% per year between 2009 and 2020. SAinfo reporterlast_img read more

18 Dec

Cape Town rolls out free Wi-Fi in public buildings

first_img21 November 2014Sixty-one public buildings in the City of Cape Town will have free Wi-Fi by the end of June 2015, the executive mayor of the city, Patricia de Lille has announced.Wi-Fi will be provided inside public buildings via the City’s 102 SmartCape computer facilities and externally via 61 public access hotspots in places where the public usually queue for services, according to De Lille.The external public amenities include clinics, administration buildings, traffic departments, fire stations and public transport interchanges in areas such as Langa, Nyanga, Uitsig, Valhalla Park, Athlone and Atlantis.In a statement De Lille said each access point will cost the City between R60 000 and R100 000 to install. “Our 102 internal public access facilities are situated inside the City’s libraries, where we currently have 679 729 registered users,’ she said.The public will be able to access free Wi-Fi at the Bellville, Robbie Nurocklinic and Khayelitsha Site B Youth clinics by the end of December this year. Members of the public visiting the Hillstar and Plumstead administrative buildings and the Mitchells Plain and Nyanga switching centres will also be able to enjoy free Wi-Fi by the end of this year as well.De Lille said the city of Cape Town is partnering with three commercial service providers – MWEB, Internet Solutions and Orange – to expand internet connectivity to previously disadvantaged communities across the city.“The partnership with Orange is a first for the Paris-based international telecommunications giant in South Africa; they will offer a free 200 MB data bundle per day. Internet Solutions will offer a free data bundle of 50 MB per day, while MWEB will provide an uncapped data bundle for the trial period,’ said De Lille.This digital inclusion project forms is part of the City’s R1.3-billion seven-year broadband network strategy. The City has a vision to become “the first truly digital city in Africa’, according to De Lille.“Our brand new Wi-Fi provision has been made possible by the City’s investment in broadband fibre optic networks in line with its City’s Universal Broadband Network strategy, which is geared towards rolling out broadband infrastructure throughout the metro,’ said De Lille, adding that by expanding broadband infrastructure, the City is well on the way to realising its vision of facilitating access to high-speed internet in order to support economic development and expand opportunities to residents.In addition, the City is mulling providing Wi-Fi on MyCiTi buses and, already, the City is in the process of conducting a pilot project with an external service provider. “We will also be accelerating the digital inclusion project by providing broadband access through the Bandwidth Barn at Lookout Hill,’ added De Lille.The public Wi-Fi project demonstrates the City’s commitment to provide broadband connectivity to all citizens, opening up opportunities in the process, according to De Lille.“Broadband connectivity and digital inclusion are fundamental to creating an enabling environment for business development, economic growth and social cohesion. Our new public Wi-Fi provision is a prime example of how the private sector, government and the public can make progress possible, together,’ said De Lille.SAinfo reporterlast_img read more

16 Dec

Martin’s 2014 Christmas Poem

first_imgWith apologies to Edgar Allan PoeOnce upon a midnight dreary,while I pondered, weak and weary,Many unpaid bills and lettersfrom my local big-box store —While I nodded, nearly napping,suddenly there came a tapping,As of someone gently rapping,rapping at my office door.“’Tis some visitor,” I muttered,“tapping at my office door —Only this and nothing more.” PREVIOUS POEMSCasey Makes a BetThe GrinchMacbethChristmas CarolsNight Before ChristmasHard it was to count my blessings; tired, I was still obsessing,Worried sick about the morrow. Vainly I had sought to borrowBackhoes, skid steers, excavators — tools I needed for the pour,For the concrete pour tomorrow — (deadline I could not ignore).Daily problems now beset me, avalanching, more and more:Ibuprophen — still I’m sore.Was I cheerful? No sir! no sir! — Christmas looming ever closer,Weather’s yucky; snow is sopping; idiots and fools are shopping.From Seattle to Atlanta, every corner has a Santa.My financial state was dire; unpaid bills were piling higher;Christmas carols always blaring — with these woes, I was past caring.Ibuprophen! I need more!Now the wind was loudly whipping through the leaky entry door,Reminding me the weatherstripping had worn out — it was no more.“When will I have time to seal up holes through which the breezes pour?Air that seeks the unsealed cracks, the leaky window, broken door?As the stack effect gets stronger, fuel bills increase more and more.Chills affect me to my core.”Soberly assessing matters, with my business all in tatters,(Thinking, in my leaky hovel: “Am I in a Dickens novel?”)Saddened by my future prospects — still I saw the comic aspectsAs I heard the gentle tapping, rapping at my office door.Winter winds were cruelly nipping, tearing at my… Start Free Trial Already a member? Log in This article is only available to GBA Prime Memberscenter_img Sign up for a free trial and get instant access to this article as well as GBA’s complete library of premium articles and construction details.last_img read more

18 Oct

Three girls rescued from Faridabad

first_imgNew Delhi: Three girls were rescued from the clutches of a person from the Faridabad area. Police said that the accused, who posed himself as an NGO official, lured the girls and told them that he can help them in getting their property share from their family relative so that they can live separately. The accused was arrested from South East Delhi. Police identified the accused as Bimal Kumar (38), an imposter who always pretends himself as a police officer from Anti Corruption Branch and mount pressure over the local police and general public for ulterior motives. Also Read – After eight years, businessman arrested for kidnap & murderDCP (south-east) Chinmoy Biswal said that on August 16 accused saw victim girls returning from the school and were going at their house. “Victims appeared to be sad and accused Bimal asked them the reason thereof. On enquiry, the girls told him that they are sisters and their parents are no more,” said DCP Biswal. They all live with their uncle and aunt at Khadda Colony. After the demise of their parents, uncle doesn’t love them as much as their parents did and they were not very happy. “The accused introduced himself as an officer from an NGO and stated to the girls that he will take care of the matter. Victim girls fell in the fascinated talks of the accused. Later they were kidnapped,” police said. According to police, Bimal was arrested earlier this year also for breaching peace and for the apprehension of committing an offence, by the Kalindi Kunj police station.last_img read more

12 Oct

Re-audit, fix blame by evening: Fadnavis on FOB collapse

first_imgMumbai: Maharashtra Chief Minister Devendra Fadnavis on Friday asked for an immediate probe to “fix primary responsibility by the evening” on all those behind the foot-overbridge (FOB) collapse that claimed six lives. He also sought a “revisit of the safety audits”, which had declared the Chhatrapati Shivaji Maharaj Terminus (CSTM) bridge “safe” but it collapsed here on Thursday at 7.40 p.m. injuring 32 others, some critically. Visiting the injured at various hospitals in south Mumbai, a grim Fadnavis said “it was an extremely serious matter” that the bridge which had already undergone a structural audit had crashed suddenly. Also Read – Squadrons which participated in Balakot air strike awarded citations on IAF Day “This also raises questions on the audits conducted on the city bridges… The structural and safety audits carried out on all the bridges need to be revisited. “I have also ordered the Municipal Commissioner to affix the ‘primary responsibility’ on the officials and police will lodge separate first information reports against them,” Fadnavis assured. The Mumbai Police have registered cases against BrihanMumbai Municipal Corporation (BMC) and Indian Railway officials charging them with negligence and culpable homicide in the bridge which crashed barely six months after the structural audit cleared it suggesting minor repairs. Also Read – SC declines Oil Min request to stay sharing of documents on Reliance penalty Late last night Fadnavis announced Rs 5 lakh ex gratia each to the kin of deceased and Rs 50,000 to the injured, besides a high-level probe into the incident. Connecting the CSMT’s suburban platform No. 1 with the B.T. Lane near The Times of India Building and the Anjuman-e-Islam School, it was used by thousands of daily suburban commuters rushing to catch the local trains on Central Railway and the Harbour Line. Although the debris below the bridge has been cleared, traffic restrictions continued on the busy D.N. Road, a traffic official said.last_img read more